Calendario de Educación Continua

Publications - ChEMTox Laboratory

School of Science and Technology

Laboratorio

 

 

  1. Carrasquillo G, Pinet-Velez N, Velez C, et al. Cell death induction of dibutyl phthalate (DBP) on primary brain cells from adult zebrafish. Pharm Pharmacol Int J. 2021;9(5):219-225. DOI: 10.15406/ppij.2021.09.00348
  2. Zayas B, Lebron V, Vélez C, et al. Novel NBQ-48 as marker of hypoxic cells in 2D and 3D colon cancer cells. J Cancer Prev Curr Res. 2020;11(1):13-18. DOI:10.15406/jcpcr.2020.11.00417
     
  3. Lafontaine-Cruz, R. E., Velez, C., & Ajay, K. (2020, October 28). Optimizacion de la Sintesis de AP-404 Utilizando Quimica Verde. Perspectivas, 8(69), 69-85. https://documento.uagm.edu/cupey/perspectivas/p_perspectivas_8_2020_69-85.pdf
     
  4. Ortiz-Jordan, L. M., Velez-Gerena, C., Soto-Nieves, N., Cox-Rosario, O., & Zayas-Rivera, B. (2020, October 28). Comparison of the toxicity of NBQ 234 TOM and NBQ 345 TOM on COLO 205 cancer cells and its fluorescent emission under hypoxic versus aerobic environments. Perspectivas, 8, 86-103. https://documento.uagm.edu/cupey/perspectivas/p_perspectivas_8_2020_86-103.pdf.
     
  5. Rios-Agosto, A. J., Velez-Gerena, C., Zayas, B., & Kumar, A. (2020, October 28). Identification of Antibiotics as Toxic Contaminants at Surface Water and Filtration Plant in the Northern Area of Puerto Rico. Perspectivas, 8(33), 33-47. https://documento.uagm.edu/cupey/perspectivas/p_perspectivas_8_2020_33-47.pdf
     
  6. Ocasio-Malavé C., Donate MJ., Sánchez M.M., et all (2019). Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cells. September 2019Bioorganic & Medicinal Chemistry Letters DOI: 10.1016/j.bmcl.2019.126760.
     
  7. Rios, K., Vélez,  C.  and  Zayas,  B.  (2019) Cell  Death  Effects  of  the  Phthalate  2-Ethyl-1-Hexanol  on  Hu-man   Linfoblast   Cells. Open   Journal   of   Apoptosis, 8, 1-15. https://doi.org/10.4236/ojapo.2019.81001 (PDF) Cell Death Effects of the Phthalate 2-Ethyl-1-Hexanol on Human Linfoblast Cells. Available from: https://www.researchgate.net/publication/334766574_Cell_Death_Effects_of_the_Phthalate_2-Ethyl-1-Hexanol_on_Human_Linfoblast_Cells [accessed Nov 07 2019].
     
  8. Vélez C., Soto J., Ríos K., Silva L., Hernandez W., Rivera LA, Ortiz-Colón A.I, Osvaldo Cox, Zayas B. (2017). Toxicity and Apoptosis Related Effects of Benzimidazo [3, 2-α] Quinolinium Salts Upon Human Lymphoma Cell.  The open medicinal chemistry journal, 2017.
     
  9. Sanabria-Ríos, D. J.; Rivera-Torres, Y., Rosario, J.; Ríos, C.; Gutierrez, R.; Carballeira, N. M.; Vélez, C.;Zayas, B.; Álvarez-Colón, F.; Ortiz-Soto, G.; Serrano, V.; Altieri-Rivera, J.; Ríos-Olivares, E.; Rodríguez, J. W. (2015). Synthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activity. Bioorg Med Chem Lett. 2015;25(10):2174-80. doi: 10.1016/j.bmcl.2015.03.065. Epub 2015 Mar 31.
     
  10. Rodríguez-Torres, M. R., Vélez, C., Arslan, Z., Gonzalez-Vega, M. N., Beltran-Huarac, J., Morell, G., Zayas, B., Primera-Pedrozo, O. M. (2015). Optimization, characterization of direct water synthesis of cadmium selenide quantum dots and cytocompatibility for colo-205 cells. J Nanopart Res (2015) 17:266 DOI 10.1007/s11051-015-3064-8.
     
  11. Otero M., Zayas B., Miranda E., Velez C., Hernandez W.J., & Osvaldo Cox (2015).  Immunomodulatory response of the unnatural alkaloid, 3-amino-7-benzylbenzimidazo[3,2-a]quinolinium chloride (ABQ-48) and 3-nitro-7-benzybenzylbenzimidazo[3,2-a]quinolinium chloride (NBQ-48). J Cancer Res Therap Oncol 2013 | Vol 2: 403 JCRTO. Open Access, 2015.
     
  12. Soto, K.T.; Guzmán-Blas, R.; Fachini, E.R.; Larios, E.; Valentín, L.; Zayas, B.; José-Yacamán, M.; Cabrera, C.R., “Highly Organized Nanofiber Formation from Zero Valent Iron Nanoparticles after Cadmium Water Remediation”, RCS Advances 2015, 5, 2777-2784. DOI: 10.1039/C4RA13267.
     
  13. Silva-Torres LA, Vélez C, Zayas B (2015) Xylazine and Its Speedball Combination: Induction of     Apoptosis by Intrinsic and Extrinsic Pathway in Human Umbilical Vein Endothelial Cells. J Subst. Abuse Alcohol 3(1): 1024.
     
  14. Vélez C., Zayas B. and Kumar A (2014). Biological activity of N-Hydroxyethyl-4-aza-2,3-didehyropodophyllotoxin derivatives upon colorectal adenocarcinoma cells. Open Journal of Medicinal Chemistry (OJMC), Vol.4, 1-11. Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, USA School of Environmental Affairs, Universidad Metropolitana, San Juan, USA
     
  15. Cox O., Vélez C., Kumar V., Malhotra S., Rivera L., Hernandez W., Martínez J. Cordero M. and Zayas B (2014). Synthesis of and Biological Study of 7-Benzyl-3-aminobenzimidazo[3,2-a]quinolinium     Chloride (ABQ-48: NSC D-763307) and 7-benzyl-3-nitrobenzimidazo[3,2-a] quinolinium Chloride (NBQ    48: NSC D-763303). Current Bioactive Compounds 2014, 10, 286-291.
     
  16. Silva-Torres L., Veléz C., Álvarez L., and Zayas B., (2014). Xylazine as a Drug of Abuse and Its         Effects on the Generation of Reactive Species and DNA Damage on Human Umbilical Vein Endothelial Cells. Journal of Toxicology Volume 2014, Article ID 492609, 8 pages. http://dx.doi.org/10.1155/2014/492609.
     
  17. Silva-Torres L.A., Vélez C., Vargas-Vidot J., Ortiz J.G and Zayas B., (2014). Toxic Effects of Xylazine on Endothelial Cells in Combination with Cocaine and Heroin. Toxicology in Vitro  28(7):1312-1319.DOI: 10.1016/j.tiv.2014.06.013
     
  18. Vélez C., Cox O., Rosado-Berrios C., Molina D., Arroyo L., Carro S., Kumar V., Malhotra S., Cordero M.,  and Zayas B. (2013). Novel nitrobenzazolo[3,2-a]quinolinium salts induce cell death through a mechanism involving DNA damage, cell cycle changes, and mitochondrial permeabilization. Open Journal of Apoptosis, Vol.2 No.2. Paper ID 30466.
     
  19. Soto K., Zayas B., Cox O., and Cabrera C. (2012). Cadmium reduction with nanoparticles of iron in heavy metals remediation. [Reducción de Cadmio con nanopartículas de hierro cerro valente para la remediación de metales pesados]. Perspectivas en Asuntos Ambientales,1(1),19-20.Soto, K.,
     
  20. Rosado C., Velez C. and Zayas B. (2011). Mitochondrial Permeability and Toxicity of Di ethylhexyl and Mono ethylhexyl Phthalates on TK6 Human Lymphoblasts Cells. Toxicology in Vitro 25  2010–2016.
     
  21. Zayas B, Beyley J, Terron M, Cordero M, Hernandez W, Alegría AE, Cox O., (2007). Comparison of the nucleic acid covalent binding capacity of two nitro-substituted benzazolo[3,2-a]quinolinium salts upon enzymatic reduction. Toxicol In Vitro. 21(6):1155-64. Epub 2007 Mar13.